Spatial framework facilitates cooperation in a very social Predicament: empirical proof from the bacterial Local community
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
‘It absolutely was basically a make any difference of finding up a book on mobile biology and beginning to examine. I'd originate from a planet of extremely-superior vacuums, cryostats and quantum phenomena, and now I used to be Functioning at space temperature with molecular biology kits.
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, developed a completely new way (‘wedging transfer’) to control nanostructures; 1st report of DNA translocation as a result of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into strong-condition nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile amount. Our jobs involve the subsequent:
Learning DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
Imagine if, as an alternative to utilizing common best-down silicon electronics, transistors could be designed from the bottom up working with single organic and natural molecules because the switching things? This idea, which grew to become The premise of nowadays’s field of molecular electronics, 1st emerged in the seventies.
There was a person problem though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers were really not this kind of excellent conductors, which was fairly disappointing. We As a result broadened our look at to try to discover far more promising molecules.
‘The concept there is such a point for a commencing, a big bang, is previously a fascinating signpost to look at that there was a creator. But more usually, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: basically, cees dekker you will discover only atoms and purely natural forces that we can measure.
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those times and recognized about 5 hundred genes which have been minimally necessary to get a operating mobile. We want to seem base-up: how can we move from a number of molecules to an entire Organic program?
Visualization of unstained DNA nanostructures with advanced in-target transmission electron microscopy strategies
The biophysicist from Delft – who has actually been Among the most cited researchers inside the Netherlands For many years – takes his obligation to lead towards the explanation and popularisation of his do the job with the border of physics and biology incredibly critically and regularly seems inside the media; Otherwise to look at his perform, then about the connection involving science and his Christian faith.